What Will Happen to COVID-19 in 2025? Experts Weigh In

Five years after the initial wave of the COVID-19 pandemic, the virus remains a significant concern globally. Despite extensive vaccination campaigns and public health measures, SARS-CoV-2 continues to evolve and circulate widely. According to experts interviewed by Newsweek, 2025 is expected to mirror 2024 in terms of COVID-19 risks, with new variants, vaccine efforts, and public health challenges shaping the year ahead. This article explores their insights and what they mean for managing the ongoing pandemic. See a summary below, or click here to read the full article on Newsweek.

What Experts Predict for 2025

Continuity in Virus Behavior

Professor Jonathan Ball, a molecular virologist and Deputy Vice Chancellor at the Liverpool School of Tropical Medicine, anticipates that 2025 will feature outbreaks linked to emerging variants and waning immunity within populations. Infectious disease epidemiologist Professor Christophe Fraser from the Pandemic Sciences Institute at the University of Oxford agrees, predicting that one or two new variants, likely descendants of Omicron, will dominate the landscape. Vaccination and natural immunity are expected to shield most people from severe disease.

Role of New Variants

Experts highlight that the emergence of a highly divergent variant could significantly alter the pandemic’s trajectory. However, Professor Ball notes that such a development is unlikely unless substantial selective pressures force dramatic changes in the virus. While not impossible, the risk of this scenario remains low under current conditions.

Challenges in Vaccine Uptake

Dr. Robert H. Hopkins Jr., medical director at the National Foundation for Infectious Diseases, identifies vaccine hesitancy and public mistrust of health authorities as significant barriers to controlling COVID-19. He emphasizes the need for better communication to rebuild trust and ensure higher vaccination rates. Hopkins underscores that current vaccines effectively prevent severe disease and death, particularly among vulnerable populations.

The Intersection of Public Health and Politics

Professor Fraser highlights the growing polarization of health matters and the difficulties faced by intergovernmental institutions in fostering international collaboration. The politicization of public health issues has hampered efforts to deliver accurate information, complicating individual decision-making about health risks.

Long COVID and Vulnerable Populations

Both Fraser and Hopkins stress the ongoing importance of addressing long COVID and prioritizing vaccination for older adults and immunocompromised individuals. As immunity wanes faster in these groups, boosters will remain essential to prevent severe outcomes.

Advances in Science and Technology

Despite the challenges, there is optimism about the role of scientific advancements in better managing COVID-19. Fraser highlights breakthroughs in sequencing, artificial intelligence, and evolutionary modeling, which allow for faster identification and characterization of new variants. This progress enables quicker adaptation of vaccines to emerging threats.

The Potential of Intranasal Vaccines

Research into intranasal vaccines offers hope for broader and longer-lasting immunity, potentially protecting against both infection and disease. While data on these vaccines is still preliminary, their development represents a promising avenue for future pandemic control.

The Role of Rapid Testing in 2025

Rapid testing remains a critical tool for identifying infections and curbing transmission. The availability of rapid home tests empowers individuals to monitor their health and make informed decisions about isolation and treatment. Widespread access to testing supports public health by enabling early detection and reducing the spread of the virus.

Key Takeaways for the Future

  1. Vaccination Efforts: Improving vaccine coverage and access will be vital for managing COVID-19 in 2025. Boosters and next-generation vaccines will play a central role.
  2. Enhanced Surveillance: Technological advances will improve our ability to monitor and respond to emerging variants.
  3. Public Health Communication: Rebuilding trust in health authorities and combating misinformation will be essential for increasing adherence to preventive measures.
  4. Support for Long COVID Patients: Addressing the needs of those with long COVID will remain a public health priority.

As COVID-19 continues to circulate, 2025 is expected to reflect the challenges and progress of the past year. While new variants may emerge, existing immunity through vaccination and prior infection offers substantial protection. Scientific and technological advancements provide hope for improved pandemic management, but public health efforts must focus on rebuilding trust and ensuring equitable access to vaccines and treatments. Tools like rapid home tests will remain indispensable for identifying infections early and protecting communities from severe outcomes.

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  • Keywords: COVID-19, 2025 pandemic, SARS-CoV-2, rapid testing, rapid home tests, variants, vaccines, public health, long COVID, future of COVID-19